FRIENDS: Best Friends Forever (from left) Greg Gaines (Thomas Mann) and Earl Johnson (RJ Cyler) switch from filming clownish parodies to make a serious documentary about cancer victim (far left) Rachel (Olivia Cooke) in “Me and Earl and the Dying Girl,” directed by Alfonso Gomez-Rejon from the young adult novel by Jesse Andrews.
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High school seniors Greg Gaines (Thomas Mann) and Earl Johnson (RJ Cyler) are not only best friends, they’re each other’s only friend, unless an empathetic history teacher counts. Mr. McCarthy (Jon Bernthal) has taken pity on the pair, letting them eat their lunch in his office to spare them the humiliation of being teased in the cafeteria on a daily basis.

Terminally-insecure Greg rationalizes their “carefully-cultivated invisibility” with the insight that, “Hot girls destroy your life.” So, instead of looking for love, the ostracized social zeros spend most of their free time shooting clownish parodies of memorable screen classics. But the 42 spoofs, sporting titles like “Eyes Wide Butt,” “A Sockwork Orange,” “Brew Velvet,” “A Box of Lips… Wow!” and “2:48 PM Cowboy,” suffer from such low-production values, that the amateur filmmakers are too embarrassed to share them with anybody.

At the start of the semester, we find Greg being pressured by his mother (Connie Britton) to visit the suddenly cancer-stricken daughter of one of her girlfriends (Molly Shannon). He agrees to do so rather reluctantly because he barely knows Rachel (Olivia Cooke), even though, until recently, she also attended Schenley High.

However, the two soon hit it off, since they’re both artsy types given to an ingratiating combination of introspection and gallows humor. Greg returns to her house again and again, doing his best to prop up her spirits during a valiant battle with leukemia in which she loses her strength and her hair as a consequence of chemotherapy.

Eventually, he enlists the assistance of his BFF in making their first documentary, a biopic dedicated to the now bed-ridden Rachel. Throwing himself into the project with an admirable zeal, he marks the production with meaningful touches like get well wishes from the patient’s family and friends, including his own repeated assurances that she’s going to beat the disease.

The only problem is that the attention paid to Rachel leaves little time for academics; and Greg’s plummeting grades have a negative effect on his college prospects.

Adapted from the Jesse Andrews young adult novel of the same name, Me and Earl and the Dying Girl is a bittersweet coming-of-age adventure directed by Alfonso Gomez-Rejon (The Town That Dreaded Sundown). The film was very warmly received at the Sundance Film Festival earlier this year where it landed both the Audience and Grand Jury Awards.

A refreshingly exhilarating, emotional and ultimately uplifting examination of youngsters forging an unbreakable bond in the face of a malignant force far beyond their control.

Excellent (****). Rated  PG-13 for profanity, sexuality, drug use and mature themes. Running time: 104 minutes. Distributor: Fox Searchlight.